These Stunning Images Will Take You On A Journey Through The Brain
Scientists reproduce gray matter in technicolor.
Harvard University scientists have discovered a new world of mystery and complexity at the micro level of the brain.
A new study authored by molecular biologist Dr. Jeff Lichtman and his colleagues and
published last week in the journal Cell offers a glimpse inside the neurons of a mouse's brain in unprecedented detail.
Lichtman told The Huffington Post that 20 scientists worked on the
six-year project, with the aim of developing high-resolution images of
the animal's brain in an effort to better understand this complex organ.
The scientists developed technologies that created digital models of
the actual brain tissue of mice, allowing researchers to examine its
detailed structural organization.
In
a series of 3D graphic images, the researchers were able to reconstruct
components of an adult mouse's brain at nanoscale resolution. They
focused specifically on the brain's neocortex, the outermost layer,
which makes up roughly three-quarters of the brain's volume. The
neocortex comprises gray matter, the tissue made up of neurons that acts
as an information-processing center.
"The goal of this study was to help us fathom this most mysterious part of biology," Lichtman said in a Harvard video about the research. "Our goal in this case was to do that by looking at brains and describing them at very high resolutions."
Using the new imaging technique, the researchers collected tens of
thousands of ultra-thin brain sections -- each one-thousandth the
thickness of a single strand of hair -- on a single film strip. They
were able to create images of these sections at high resolution by using
new software tools to color the neural connections.
Scroll down for more high-resolution images of a mouse brain in technicolor detail:
The image above depicts a brain cell, also known as a neuron, which
is designed to carry electrochemical messages through the nervous
system. (
Click here for a diagram and detailed breakdown.) You can see
axons, or nerve fibers (pictured in blue, purple and green), which bundle together at junctions called
synapses -- the bridges between neurons that allow the cells to communicate with one another.
The axons are attached to the
dendrite (pictured in red), a
branch-like extension of a neuron, which receives electrical impulses
from other cells and communicates them to the neuron. These electrical
impulses are how the brain registers external things like sunlight or
cold, as well as internal messages from other parts of the body.
In this close-up image you can see a high-resolution view of the
synapses
(which, again, are the connectors responsible for communication between
neurons) running along the branch of a dendrite. Those little white
dots inside the axons are
synaptic vesicles, and they are
responsible for storing the neurotransmitters that are released at the
synapse. These neurotransmitters carry information throughout the brain
and the body, and can affect things like mood and sleep.
This reconstruction of one brain section shows large dendrites
(pictured above and below in red) surrounded by other parts of the
neuron.
The image above shows a batch of neurons extending long dendrite branches.
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